Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years

High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged ≥80 y (oldest old) remains unclear. We investigated the as...

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Bibliographic Details
Published in:The Journal of nutrition 2019-06, Vol.149 (6), p.1056-1064
Main Authors: Mao, Chen, Li, Fu-Rong, Yin, Zhao-Xue, Lv, Yue-Bin, Luo, Jie-Si, Yuan, Jin-Qiu, Mhungu, Florence, Wang, Jiao-Nan, Shi, Wan-Ying, Zhou, Jin-Hui, Chen, Guo-Chong, Gao, Xiang, Kraus, Virginia Byers, Wu, Xian-Bo, Shi, Xiao-Ming
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
Adults
Age
Age Factors
Aged, 80 and over
Aging - blood
Asian People - statistics & numerical data
Biomarkers
Biomarkers - blood
China - epidemiology
Cohort Studies
Community-based
Epidemiology
Female
Hazards
Humans
Longevity - physiology
Longitudinal Studies
Male
Men
Minority & ethnic groups
Mortality
Older people
oldest old
Original
Population studies
Proportional Hazards Models
Prospective Studies
Quartiles
Regression analysis
Regression models
Risk Factors
Risk management
Sensitivity analysis
Subgroups
Supplements
survival
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged ≥80 y (oldest old) remains unclear. We investigated the association between plasma [25(OH)D] concentration and all-cause mortality among Chinese adults aged ≥80 y. The present study is a prospective cohort study of 2185 Chinese older adults (median age: 93 y). Prospective all-cause mortality data were analyzed for survival in relation to plasma 25(OH)D using Cox proportional hazards regression models, with adjustments for potential sociodemographic and lifestyle confounders and biomarkers. The associations were measured with HR and 95% CIs. The median plasma 25(OH)D concentration was 34.4 nmol/L at baseline. Over the 5466 person-year follow-up period, 1100 deaths were identified. Men and women were analyzed together as no effect modification by sex was found. After adjusting for multiple potential confounders, the risk of all-cause mortality decreased as the plasma 25(OH)D concentration increased (P-trend
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/nxz041