Pulmonary Tumor Thrombotic Microangiopathy Mimicking Inhalation Lung Injury

Pulmonary tumor thrombotic microangiopathy (PTTM) is a complication characterized by dyspnea, pulmonary hypertension, and occasionally sudden death. We encountered a man who developed PTTM and had an inhalation history of chemical herbicides and abnormal findings on chest computed tomography, mimick...

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Bibliographic Details
Published in:Internal Medicine 2019/05/01, Vol.58(9), pp.1311-1314
Main Authors: Tateishi, Akiko, Nakashima, Kei, Hoshi, Kazuei, Oyama, Yu, Ebisudani, Toshiki, Misawa, Masafumi, Aoshima, Masahiro
Format: Article
Language:English
Subjects:
Adenocarcinoma
Anticoagulants
Autopsies
Autopsy
Biopsy
Case Report
Chemotherapy
Computed tomography
Dyspnea
Gastric cancer
gastric carcinoma
Herbicides
Inhalation
inhalation lung injury
Internal medicine
Lung diseases
Mimicry
pulmonary hypertension
pulmonary tumor thrombotic microangiopathy
Respiration
signet ring cell carcinoma
Thrombotic microangiopathy
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Summary:Pulmonary tumor thrombotic microangiopathy (PTTM) is a complication characterized by dyspnea, pulmonary hypertension, and occasionally sudden death. We encountered a man who developed PTTM and had an inhalation history of chemical herbicides and abnormal findings on chest computed tomography, mimicking chemical inhalation lung injury. He was diagnosed with PTTM with adenocarcinoma by a transbronchial lung biopsy and received chemotherapy and anticoagulant therapy. He survived for one month. An autopsy revealed primary gastric cancer with PTTM that can have a presentation similar to diffuse pulmonary diseases, including chemical inhalation lung injury. The examination of a biopsy specimen is crucial in such patients.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1796-18