All hands on DEK

In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted by macrophages and other cells, but no function has been attached to secreted DEK. Capitano et al. showed that extracellu...

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Bibliographic Details
Published in:The Journal of clinical investigation 2019-06, Vol.129 (6), p.2205-2206
Main Author: Bodine, David M
Format: Article
Language:English
Subjects:
Acute myelocytic leukemia
Arthritis
Biomedical research
Bone marrow transplantation
Cell proliferation
Chromatin
Chromosomal Proteins, Non-Histone
Conflicts of interest
Cytokines
Deoxyribonucleic acid
DNA
Experiments
Genes
Genetic research
Hematopoiesis
Hematopoietic Stem Cells
Heparan sulfate
Humans
Inflammation
Leukemia
Localization
Macrophages
Myeloid leukemia
Nuclear Proteins
Oncogene Proteins
Poly-ADP-Ribose Binding Proteins
Progenitor cells
Proteins
Signal Transduction
Stem cell transplantation
Stem cells
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Summary:In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted by macrophages and other cells, but no function has been attached to secreted DEK. Capitano et al. showed that extracellular DEK activates signaling through the CXCL2 receptor, which in turn enhances the proliferation of hematopoietic stem cells and decreases hematopoietic progenitor cell numbers both in vivo and in vitro. These results offer the opportunity to expand transplantable stem cells to improve outcomes in patients undergoing bone marrow transplant.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI128986