Bipolar disorder and psychotropic medication: Impact on pregnancy and neonatal outcomes

•Women with bipolar disorder who are treated with psychotropic drugs in pregnancy differ substantially from women are not medicated and women who have neither medication exposure nor bipolar disorder, which makes assessment of reproductive outcomes subject to confounding by indication.•In this study...

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Bibliographic Details
Published in:Journal of affective disorders 2019-01, Vol.243, p.220-225
Main Authors: Wisner, Katherine L., Sit, Dorothy, O'Shea, Kelly, Bogen, Debra L., Clark, Crystal T., Pinheiro, Emily, Yang, Amy, Ciolino, Jody D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bipolar Disorder - drug therapy
Case-Control Studies
Female
Humans
Infant
Infant, Newborn
Male
Newborn
Pennsylvania - epidemiology
Perinatal psychiatry
Postpartum
Pregnancy
Pregnancy Complications - chemically induced
Pregnancy Complications - epidemiology
Pregnancy Outcome - epidemiology
Premature Birth - epidemiology
Prospective Studies
Psychopharmacology
Psychotropic Drugs - adverse effects
Psychotropic Drugs - therapeutic use
Socioeconomic Factors
Young Adult
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Summary:•Women with bipolar disorder who are treated with psychotropic drugs in pregnancy differ substantially from women are not medicated and women who have neither medication exposure nor bipolar disorder, which makes assessment of reproductive outcomes subject to confounding by indication.•In this study, about 10% of infants were delivered preterm across exposure groups, and no significant differences in outcome occurred for APGAR scores 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2018.09.045