Comparison between physical and cognitive treatment in patients with MIC and Alzheimer’s disease

Cognitive and physical activity treatments (CT and PT) are two non-pharmacological approaches frequently used in patients with Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). The aim of this study was to compare CT and PT in these diseases. Eighty-seven patients were randomly assigned...

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Published in:Aging (Albany, NY.) NY.), 2019-05, Vol.11 (10), p.3138-3155
Main Authors: Fonte, Cristina, Smania, Nicola, Pedrinolla, Anna, Munari, Daniele, Gandolfi, Marialuisa, Picelli, Alessandro, Varalta, Valentina, Benetti, Maria V., Brugnera, Annalisa, Federico, Angela, Muti, Ettore, Tamburin, Stefano, Schena, Federico, Venturelli, Massimo
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Language:English
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Research Paper
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Summary:Cognitive and physical activity treatments (CT and PT) are two non-pharmacological approaches frequently used in patients with Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). The aim of this study was to compare CT and PT in these diseases. Eighty-seven patients were randomly assigned to CT (n=30), PT (n=27) or control group (CTRL; n=30) for 6 months. The global cognitive function was measured by Mini Mental State Examination (MMSE). Specific neuropsychological tests explored attention, memory, executive functions, behavioral disorders. Cardiovascular risk factors (CVD) were collected. All measures were performed before (T0), after treatments (T1), and at three-months follow-up (T2). MMSE did not change from T0 to T1 and T2 in patients assigned to PT and CT, while CTRL patients showed a decline MCI: -11.8%, AD: -16.2%). Between group differences (MCI vs AD) were not found at T1 and T2. Significant worsening was found for CTRL in MCI (T0- T1: P =.039; T0-T2: P
ISSN:1945-4589
DOI:10.18632/aging.101970