Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study

The Cold Pressor Test (CPT) is a novel diagnostic strategy to noninvasively assess the myocardial microvascular endothelial-dependent function using perfusion magnetic resonance imaging (MRI). Spleen perfusion is modulated by a complex combination of several mechanisms involving the autonomic nervou...

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Bibliographic Details
Published in:BioMed research international 2019-01, Vol.2019 (2019), p.1-7
Main Authors: Catalano, Carlo, Carbone, Iacopo, Rosato, E., Bracci, Angelica, Pambianchi, Giacomo, Borrazzo, Cristian, Cundari, Giulia, Galea, Nicola, Francone, Marco
Format: Article
Language:English
Subjects:
Adenosine
Adequacy
Adult
Atherosclerosis
Autonomic nervous system
Blood
Blood flow
Cold
Cold Temperature
Diagnostic systems
Endothelium
Female
Gadolinium
Heart Ventricles - diagnostic imaging
Hemodynamics
Humans
Hypertension
Hypothermia, Induced - methods
Magnetic Resonance Angiography - methods
Magnetic resonance imaging
Male
Microvasculature
Middle Aged
Myocardial Perfusion Imaging - methods
Myocardium - pathology
Nitric oxide
NMR
Nuclear magnetic resonance
Perfusion
Physiology
Regional Blood Flow - physiology
Resonance
Rest
Smooth muscle
Spleen
Spleen - blood supply
Spleen - diagnostic imaging
Standard deviation
Statistical analysis
Vasoactive agents
Ventricle
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Summary:The Cold Pressor Test (CPT) is a novel diagnostic strategy to noninvasively assess the myocardial microvascular endothelial-dependent function using perfusion magnetic resonance imaging (MRI). Spleen perfusion is modulated by a complex combination of several mechanisms involving the autonomic nervous system and vasoactive mediators release. In this context, the effects of cold temperature on splenic blood flow (SBF) still need to be clarified. Ten healthy subjects were studied by MRI. MRI protocol included the acquisition of GRE T1-weighted sequence (“first pass perfusion”) during gadolinium administration (0.1mmol/kg of Gd-DOTA at flow of 3.0 ml/s), at rest and after CPT. Myocardial blood flow (MBF) and SBF were measured by applying Fermi function deconvolution, using the blood pool input function sampled from the left ventricle cavity. MBF and SBF values after performing CPT were significantly higher than rest values (SBF at rest: 0.65 ± 0.15 ml/min/g Vs. SBF after CPT: 0.90 ± 0.14 ml/min/g, p:
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/8437927