Androgen receptor promotes oral squamous cell carcinoma cell migration by increasing EGFR phosphorylation

This study is aimed to investigate the role of androgen receptor (AR) in regulating oral squamous cell carcinoma (OSCC) cells migration. Tumors from 23 patients with OSCC and five OSCC cell lines were used for analyzing AR expression. The effects of AR agonist and antagonist were used to examine the...

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Bibliographic Details
Published in:OncoTargets and therapy 2019-06, Vol.12, p.4245-4252
Main Authors: Liu, Xin, Qing, Shanglan, Che, Keke, Li, Lihua, Liao, Xiaoming
Format: Article
Language:English
Subjects:
Androgens
Cancer
Carcinoma
Cetuximab
Epidermal growth factors
Original Research
Sex hormones
Squamous cell carcinoma
Tumors
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Summary:This study is aimed to investigate the role of androgen receptor (AR) in regulating oral squamous cell carcinoma (OSCC) cells migration. Tumors from 23 patients with OSCC and five OSCC cell lines were used for analyzing AR expression. The effects of AR agonist and antagonist were used to examine the role of AR in regulating the migration of OSCC cells. Ten of 23 tumors from patients with OSCC were AR positive. There was no significant difference in total EGFR (tEGFR) expression between AR-positive tumors and AR-negative tumors. However, the expression of phosphorylated EGFR (pEGFR) in AR-positive tumors was significantly higher than that in AR-negative tumors (
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S200718