Is there a threshold that triggers cortical arousals in obstructive sleep apnea

• Published in: Sleep (New York, N.Y.) N.Y.), 2019-06, Vol.42 (6), p.1
• Main Authors: Li, Yanru, Orr, Jeremy, Jen, Rachel, Sands, Scott A, DeYoung, Pamela, Smales, Erik, Edwards, Bradley, Owens, Robert L, Malhotra, Atul
• Format: Article
• Language: English
• Subjects: Adult; Apnea; Arousal - physiology; Brain; Clinical trials; Comparative analysis; Epiglottis - physiology; Eszopiclone; Female; Humans; Male; Medical research; Middle Aged; Polysomnography - methods; Respiration; Sleep apnea; Sleep Apnea, Obstructive - physiopathology; Sleep Disordered Breathing; Sleep Stages - physiology
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsz047

To determine whether there is a consistent epiglottic pressure value that predicts respiratory arousal from sleep. Thirty-one patients with obstructive sleep apnea underwent overnight polysomnography while instrumented with an epiglottic catheter to measure airway pressures. Nadir epiglottic pressures during respiration events (obstructive apneas/hypopneas) terminated with or without arousals were compared. The events were selected by two methods, (1) 20 events with/without arousals were randomly selected, and (2) Events were sampled in pairs (one terminated with arousal and one without arousal) to minimize the effect of sleep duration/stage on the measurement. A total of 1,317 respiratory events were analyzed. There was substantial variability in nadir epiglottic pressure within an individual and among different individuals. The average pressure of 20 randomly selected events with arousals was (-21.2 ± 11.2, ranged -6.68 to -63.34 cm H2O). The nadir epiglottic pressure during respiratory events in NREM stage 2 sleep terminated with arousals was more negative compared with those terminated without arousals using both sampling methods (-23.5 vs. -18.5 cm H2O, p = 0.007 and -20.3 vs. -16.3 cm H2O, p < 0.001). There were very different levels of epiglottic pressures that preceded arousals within and among individuals. However, cortical arousals are associated with a level of more negative epiglottic pressure compared to events terminated without arousal, findings which support the concept of a respiratory arousal threshold. The study used existing data to study methodology (from clinical trial "The Impact of Arousal Threshold in Obstructive Sleep Apnea" https://clinicaltrials.gov/show/NCT02264353) and it is not a clinical trial.