The Evaluation of Glutathione Reductase and Malondialdehyde Levels in Patients With Lumbar Disc Degeneration Disease

Increased oxidative stress plays a crucial role in pathogenesis of various diseases. The present study aims to investigate glutathione reductase (GR) and malondialdehyde (MDA) enzymes as markers of oxidative stress mechanisms in lumbar disc degeneration disease (LDDD). The study group consisted of 3...

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Bibliographic Details
Published in:In vivo (Athens) 2019-05, Vol.33 (3), p.811-814
Main Authors: Bakirezer, Selvi Duman, Yaltirik, Cumhur Kaan, Kaya, Ahmet Hilmi, Yilmaz, Seda Gulec, Ozdogan, Selcuk, Billur, Deryanaz, Isbir, Turgay
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Case-Control Studies
Female
Glutathione Reductase - metabolism
Humans
Intervertebral Disc Degeneration - metabolism
Lumbar Vertebrae
Male
Malondialdehyde - metabolism
Middle Aged
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Summary:Increased oxidative stress plays a crucial role in pathogenesis of various diseases. The present study aims to investigate glutathione reductase (GR) and malondialdehyde (MDA) enzymes as markers of oxidative stress mechanisms in lumbar disc degeneration disease (LDDD). The study group consisted of 39 patients diagnosed with LDD and 37 healthy individuals in the control group. The enzyme-linked immunosorbent assay (ELISA) method was used to determine serum GR and MDA levels in the two study groups. Serum GR levels were significantly lower (p=0.008), while MDA levels were significantly higher in the patient group compared to the controls (p=0.025). Oxidative stress mechanisms play a crucial role in disc degeneration and GR deficiency could be an eligible risk factor for LDDD.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11543