General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis

The purpose of this study was to investigate the relationship between clinical disease activity in patients with advanced stage rheumatoid arthritis (RA) on treatment with Disease Modifying Antirheumatic Drugs (DMARDs) and histopathological scores of synovial inflammation. To this end, synovial biop...

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Bibliographic Details
Published in:Scientific reports 2019-06, Vol.9 (1), p.8448-8448, Article 8448
Main Authors: Schmidt, Tobias, Najm, Aurélie, Mussawy, Haider, Burghardt, Rolf, Oehler, Nicola, Krenn, Veit, Rüther, Wolfgang, Niemeier, Andreas
Format: Article
Language:English
Subjects:
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Adult
Aged
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - surgery
Arthroplasty
Autoimmune diseases
Biopsy
CD20 antigen
CD3 antigen
CD3 Complex - genetics
CD3 Complex - immunology
Female
Gene Expression Regulation - immunology
Heterogeneity
Humanities and Social Sciences
Humans
Inflammation
Inflammation - genetics
Inflammation - immunology
Inflammation - surgery
Joint diseases
Joint surgery
Lewis X Antigen - genetics
Lewis X Antigen - immunology
Lymphocytes B
Lymphocytes T
Macrophages
Macrophages - immunology
Macrophages - pathology
Male
Methotrexate
Middle Aged
multidisciplinary
Patients
Prednisolone
Rheumatoid arthritis
Science
Science (multidisciplinary)
Severity of Illness Index
Surgery
Synovial Fluid - immunology
Synovial Fluid - metabolism
Synovitis
Synovitis - immunology
Synovitis - metabolism
Synovitis - surgery
Tumor necrosis factor-α
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Description
Summary:The purpose of this study was to investigate the relationship between clinical disease activity in patients with advanced stage rheumatoid arthritis (RA) on treatment with Disease Modifying Antirheumatic Drugs (DMARDs) and histopathological scores of synovial inflammation. To this end, synovial biopsies of 62 RA patients who underwent surgery for either synovectomy or total joint arthroplasty were assessed by a general synovitis score (GSS) and an immunologic synovitis score (IMSYC). The clinical disease activity index (CDAI) was significantly correlated with both the GSS and the IMSYC (r = 0.65, p = 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44895-9