Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control?

Park et al. (2019) create a synthetic self-propagating adenine methylation system for epigenetic control in human cells. Targeting adenine allows their modular system to act orthogonally to most epigenetic processes, thereby opening the door for novel methods of controlling gene expression. Park et ...

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Bibliographic Details
Published in:Molecular cell 2019-04, Vol.74 (1), p.5-7
Main Authors: Chang, Timothy Z., Kuo, James, Silver, Pamela A.
Format: Article
Language:English
Subjects:
DNA Methylation
Epigenesis, Genetic
Gene Expression
Humans
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Summary:Park et al. (2019) create a synthetic self-propagating adenine methylation system for epigenetic control in human cells. Targeting adenine allows their modular system to act orthogonally to most epigenetic processes, thereby opening the door for novel methods of controlling gene expression. Park et al. (2019) create a synthetic self-propagating adenine methylation system for epigenetic control in human cells. Targeting adenine allows their modular system to act orthogonally to most epigenetic processes, thereby opening the door for novel methods of controlling gene expression.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2019.03.016