Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis

Immunocytochemical methods were used to identify neurons in the ventral posterior nucleus of the cat and Galago senegalensis that contain glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory neurotransmitter, GABA. In both species GAD-immunoreactive neurons make up about 30% of...

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Bibliographic Details
Published in:The Journal of neuroscience 1983-09, Vol.3 (9), p.1868-1887
Main Authors: Penny, GR, Fitzpatrick, D, Schmechel, DE, Diamond, IT
Format: Article
Language:English
Subjects:
Animals
Carboxy-Lyases - analysis
Cats - metabolism
Galago - metabolism
Galago senegalensis
Glutamate Decarboxylase - analysis
Glutamate Decarboxylase - immunology
Horseradish Peroxidase
Immunochemistry
Neurons - analysis
Neurons - immunology
Thalamic Nuclei - cytology
Thalamic Nuclei - immunology
Thalamic Nuclei - metabolism
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Summary:Immunocytochemical methods were used to identify neurons in the ventral posterior nucleus of the cat and Galago senegalensis that contain glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory neurotransmitter, GABA. In both species GAD-immunoreactive neurons make up about 30% of the total neurons in the ventral posterior nucleus and form a distinct class of small cells. After cortical injections of horseradish peroxidase (HRP), GAD-immunoreactive cells are not labeled with HRP and may, therefore, be GABAergic local circuit neurons. Comparison of the dendritic morphology of GAD-immunoreactive neurons with that of HRP-filled projection neurons reveals that the morphology of the GAD-containing neurons is distinct and, in particular, that the GAD-immunoreactive neurons display fewer primary dendrites. The relay neurons, in turn, can be divided into classes based on dendritic morphology and cell body size.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.03-09-01868.1983