Effects of amphetamine on intracellular responses of caudate neurons in the cat

The effects of acute administration of amphetamine on membrane potentials and evoked postsynaptic potentials of caudate neurons in cats were assessed using intracellular recording. High doses of amphetamine (0.5 mg/kg, i.v.) produced a reversible depolarization of the cell membrane in 78% of cells t...

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Bibliographic Details
Published in:The Journal of neuroscience 1984-04, Vol.4 (4), p.930-938
Main Authors: Schneider, JS, Levine, MS, Hull, CD, Buchwald, NA
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cats
Caudate Nucleus - cytology
Caudate Nucleus - drug effects
Dextroamphetamine - pharmacology
Evoked Potentials - drug effects
Female
Intracellular Membranes - drug effects
Male
Medical sciences
Membrane Potentials - drug effects
Neurons - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Synapses - drug effects
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Summary:The effects of acute administration of amphetamine on membrane potentials and evoked postsynaptic potentials of caudate neurons in cats were assessed using intracellular recording. High doses of amphetamine (0.5 mg/kg, i.v.) produced a reversible depolarization of the cell membrane in 78% of cells tested. Low doses (0.1 mg/kg) had no effect on the resting membrane potential. Long-lasting increases in amplitude of both excitatory and inhibitory components of evoked postsynaptic potential sequences were observed after both high and low doses of amphetamine. These changes were more evident to cortical than to substantia nigra or to intralaminar thalamic stimulation. These results were shown to be independent of the peripheral autonomic actions of amphetamine. These effects appear to be mediated by the ability of amphetamine to alter catecholaminergic mechanisms in the caudate nucleus and suggest that increased dopamine release may have a facilitatory effect on both excitatory and inhibitory synaptic transmission.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.04-04-00930.1984