Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review

Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators, bisphosphonates, anti-receptor activator of nuclear factor κB ligand antibody along with calcium and vitamin D supplementations)...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-05, Vol.20 (10), p.2557
Main Authors: Ukon, Yuichiro, Makino, Takahiro, Kodama, Joe, Tsukazaki, Hiroyuki, Tateiwa, Daisuke, Yoshikawa, Hideki, Kaito, Takashi
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Animals
Atrophy
Biomedical materials
Bone Density Conservation Agents - therapeutic use
Bone mineral density
Bones
Calciferol
Calcitriol
Calcium
Clinical trials
Dietary intake
Diphosphonates - therapeutic use
Drugs
Estrogen Receptor Modulators - therapeutic use
Fractures
Geriatrics
Homeostasis
Humans
Hyperparathyroidism
Kinases
Literature reviews
Meta-analysis
Metabolism
Metabolites
Muscles
Nutrient deficiency
Osteoporosis
Osteoporosis - drug therapy
Osteoporosis - metabolism
Osteoporosis - therapy
Patients
Review
Stem Cell Transplantation - methods
Stem cells
Systematic review
Transcription factors
Vitamin D
Vitamin D - therapeutic use
Vitamin D3
Vitamin deficiency
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Summary:Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators, bisphosphonates, anti-receptor activator of nuclear factor κB ligand antibody along with calcium and vitamin D supplementations) and anabolic agents (parathyroid hormone and related peptide analogs, sclerostin inhibitors) have major roles in current treatment regimens and are used alone or in combination based on the pathological condition. Recent advancements in the molecular understanding of bone metabolism and in bioengineering will open the door to future treatment paradigms for osteoporosis, including antibody agents, stem cells, and gene therapies. This review provides an overview of the molecular mechanisms, clinical evidence, and potential adverse effects of drugs that are currently used or under development for the treatment of osteoporosis to aid clinicians in deciding how to select the best treatment option.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20102557