Roles of hyaluronan in cardiovascular and nervous system disorders

Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2019-05, Vol.20 (5), p.428-436
Main Authors: Ding, Hong-yan, Xie, Ya-nan, Dong, Qiang, Kimata, Koji, Nishida, Yoshihiro, Ishiguro, Naoki, Zhuo, Li-sheng
Format: Article
Language:English
Subjects:
Aging
Animals
Arteriosclerosis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - physiopathology
Biological properties
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Brain - physiopathology
Cardiovascular Diseases - metabolism
Cell Movement
Cellular structure
Cerebral infarction
Clinical trials
Disorders
Extracellular matrix
Extracellular Matrix - metabolism
Heart - embryology
Heart - physiopathology
Humans
Hyaluronic acid
Hyaluronic Acid - physiology
Medical research
Multiple Sclerosis - physiopathology
Myocardial infarction
Myocardial Infarction - metabolism
Nervous system
Nervous System Diseases - metabolism
Protein Binding
Review
Seizures - physiopathology
Signal Transduction
Spinal Cord Injuries - physiopathology
Stroke - physiopathology
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Summary:Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1900155