Rapid remodeling of sensory endings in the corneas of living mice

The terminals of trigeminal neurons were followed over time in the corneas of living mice by repeated staining with a nontoxic fluorescent dye. The purpose of these observations was to evaluate remodeling of sensory nerve endings in an adult mammal. Video images of topically stained nerve endings wi...

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Bibliographic Details
Published in:The Journal of neuroscience 1989-06, Vol.9 (6), p.2210-2214
Main Authors: Harris, LW, Purves, D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cornea - innervation
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Male
Mice
Nerve Endings - cytology
Nerve Endings - physiology
Neuronal Plasticity
Neurons, Afferent - physiology
Time Factors
Vertebrates: nervous system and sense organs
Citations: Items that cite this one
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Summary:The terminals of trigeminal neurons were followed over time in the corneas of living mice by repeated staining with a nontoxic fluorescent dye. The purpose of these observations was to evaluate remodeling of sensory nerve endings in an adult mammal. Video images of topically stained nerve endings within particular corneal regions were recorded initially, and then again after intervals ranging from 4 hr to 30 d. Comparison of the 2 sets of images showed that sensory endings in the corneal epithelium undergo continual rearrangement under normal circumstances. Substantial changes in terminal configuration occurred over periods as brief as a day.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.09-06-02210.1989