Low Plasma Oxytocin Levels and Increased Psychopathology in Hypopituitary Men With Diabetes Insipidus

• Published in: The journal of clinical endocrinology and metabolism 2019-08, Vol.104 (8), p.3181-3191
• Main Authors: Aulinas, Anna, Plessow, Franziska, Asanza, Elisa, Silva, Lisseth, Marengi, Dean A, Fan, WuQiang, Abedi, Parisa, Verbalis, Joseph, Tritos, Nicholas A, Nachtigall, Lisa, Faje, Alexander T, Miller, Karen K, Lawson, Elizabeth A
• Format: Article
• Language: English
• Subjects: Adult; Alexithymia; Anxiety; Arginine Vasopressin - blood; Body mass index; Clinical s; Comparative analysis; Cross-Sectional Studies; Diabetes; Diabetes insipidus; Diabetes Insipidus - blood; Diabetes Insipidus - psychology; Diabetics; Emotions; Humans; Hypopituitarism - blood; Hypopituitarism - psychology; Hypothalamo-Hypophyseal System - physiology; Male; Medical research; Medicine, Experimental; Middle Aged; Oxytocin; Oxytocin - blood; Oxytocin - deficiency; Pituitary (anterior); Plasma; Psychological aspects; Psychology, Pathological; Psychopathology; Quality of Life; Vasopressin
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2018-02608

Abstract Context Oxytocin (OT) and vasopressin share anatomical pathways of synthesis and secretion, and patients with central diabetes insipidus (CDI) presumably are at risk for OT deficiency. However, an OT-deficient state in hypopituitary patients has not been established. Objectives We hypothesized that men with CDI compared to patients with similar anterior pituitary deficiencies (APD) but no CDI and healthy controls (HC) of similar age and body mass index, would have lower plasma OT levels, associated with increased psychopathology. Design Cross-sectional. Setting Clinical research center. Participants Sixty-two men (20 CDI, 20 APD, 22 HC), age 18 to 60 years. Interventions Frequent sampling of blood every 5 minutes for OT over 1 hour and validated questionnaires to assess psychopathology. Main Outcomes Pooled plasma OT levels; depressive, anxiety, and alexithymia symptoms; and quality of life. Results The mean 1-hour pool of fasting OT levels was lower in CDI compared with APD and HC (P = 0.02 and P = 0.009, respectively), with no differences between APD and HC (P = 0.78). Symptoms of depression, anxiety, and alexithymia were more pronounced in CDI than in HC (P = 0.001, P = 0.004, and P = 0.02, respectively). Although CDI and APD reported worse physical health compared with HC (P = 0.001 and P = 0.005) with no differences between APD and CDI, only CDI reported worse mental health compared with HC (P = 0.009). Conclusions We have demonstrated low plasma OT levels and increased psychopathology in hypopituitary men with CDI, suggestive of a possible OT-deficient state. Larger studies of both sexes are required to confirm these findings and clinically characterize hypopituitary patients with OT deficiency. Plasma OT levels are low and psychopathy is increased in hypopituitary men with CDI, suggestive of a possible OT-deficient state.