Identification of mammalian noggin and its expression in the adult nervous system

The multiple roles of noggin during dorsal fate specification in Xenopus embryos, together with noggin's ability to directly induce neural tissue, inspired an effort to determine whether a similar molecule exists in mammals. Here we describe the identification of human and rat noggin and explor...

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Bibliographic Details
Published in:The Journal of neuroscience 1995-09, Vol.15 (9), p.6077-6084
Main Authors: Valenzuela, DM, Economides, AN, Rojas, E, Lamb, TM, Nunez, L, Jones, P, Lp, NY, Espinosa, R, 3rd, Brannan, CI, Gilbert, DJ
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain - metabolism
Carrier Proteins
Chromosome Mapping
Embryo, Mammalian - drug effects
Embryo, Nonmammalian
Female
Humans
Male
Mammalia
Mice - genetics
Molecular Sequence Data
Nervous System - metabolism
Oligonucleotide Probes - genetics
Proteins - genetics
Proteins - metabolism
Proteins - pharmacology
Rats
Tissue Distribution
Xenopus - embryology
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Summary:The multiple roles of noggin during dorsal fate specification in Xenopus embryos, together with noggin's ability to directly induce neural tissue, inspired an effort to determine whether a similar molecule exists in mammals. Here we describe the identification of human and rat noggin and explore their expression patterns; we also localize the human NOGGIN gene to chromosome 17q22, and the mouse gene to a syntenic region of chromosome 11. Mammalian noggin is remarkably similar in its sequence to Xenopus noggin, and is similarly active in induction assays performed on Xenopus embryo tissues. In the adult mammal, noggin is most notably expressed in particular regions of the nervous system, such as the tufted cells of the olfactory bulb, the piriform cortex of the brain, and the Purkinje cells of the cerebellum, suggesting that one of the earliest acting neural inducers also has important roles in the adult nervous system.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.15-09-06077.1995