Toward Personalized Medicine in Bronchiolitis

In this issue of the Journal, Jones and colleagues (pp. 1537–1549) perform transcriptomics profiling of peripheral blood mononuclear cells and nasal mucosal scrapings from 26 infants and 27 young children who suffered acute bronchiolitis, and provide evidence supporting the need to discriminate appl...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2019-06, Vol.199 (12), p.1456-1458
Main Authors: Paggi, Damián Alvarez, Polack, Fernando P
Format: Article
Language:English
Subjects:
Antiviral drugs
Asthma
Bronchiolitis
Bronchiolitis, Viral
Child
Dendritic cells
Disease
Gene expression
Humans
Illnesses
Infections
Influenza
Interferon
Pathogenesis
Pediatrics
Precision Medicine
Respiratory syncytial virus
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this issue of the Journal, Jones and colleagues (pp. 1537–1549) perform transcriptomics profiling of peripheral blood mononuclear cells and nasal mucosal scrapings from 26 infants and 27 young children who suffered acute bronchiolitis, and provide evidence supporting the need to discriminate apples from oranges. [...]type I IFN levels peak early after infection, and RSV bronchiolitis has a long incubation period followed by a prodromal phase. [...]samples may have been collected too late in earlier studies to detect its antiviral effects (9). Global gene expression profiling in infants with acute respiratory syncytial virus broncholitis demonstrates systemic activation of interferon signaling networks.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201812-2371ED