A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study

Background A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study. Methods Fifteen patients with g...

Full description

Saved in:
Bibliographic Details
Published in:Acta neurochirurgica 2019-07, Vol.161 (7), p.1475-1486
Main Authors: Unsgård, Geirmund, Sagberg, Lisa Millgård, Müller, Sébastien, Selbekk, Tormod
Format: Article
Language:English
Subjects:
Acoustic noise
Adult
Artefacts
Brain cancer
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - surgery
Brain tumors
Complications
Female
Glioblastoma
Glioblastoma - diagnostic imaging
Glioblastoma - surgery
Humans
Image acquisition
Image quality
Imaging, Three-Dimensional - methods
Imaging, Three-Dimensional - standards
Interventional Radiology
Male
Medicine
Medicine & Public Health
Middle Aged
Minimally Invasive Surgery
Monitoring, Intraoperative - methods
Monitoring, Intraoperative - standards
Neuroimaging
Neurology
Neuroradiology
Neurosurgery
Neurosurgical Procedures - adverse effects
Neurosurgical Procedures - methods
Noise
Original - Brain Tumors
Original Article - Brain Tumors
Patients
Postoperative Complications - epidemiology
Signal-To-Noise Ratio
Surgeons
Surgery
Surgical Orthopedics
Ultrasonic imaging
Ultrasonography - methods
Ultrasonography - standards
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study. Methods Fifteen patients with glioblastoma (WHO grade IV) were included. All adverse events were registered in a 6-month study period. During acquisition of 3D ultrasound image volumes, three different concentrations of the ACF and Ringer’s solution were filled into the resection cavity. The effect of ACF on the ultrasound images was rated by the operating surgeon, and by five independent neurosurgeons evaluating a pair of blinded images from all patients. Images from all patients were analysed by comparing pixel brightness in a noise-affected region and a reference region. Results The operating surgeon deemed the ACF images to have less noise than images obtained with Ringers’s solution. The blinded evaluations by the independent neurosurgeons were significantly in favour of ACF ( p  
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-019-03945-x