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A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study
Background A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study. Methods Fifteen patients with g...
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| Published in: | Acta neurochirurgica 2019-07, Vol.161 (7), p.1475-1486 |
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| container_title | Acta neurochirurgica |
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| creator | Unsgård, Geirmund Sagberg, Lisa Millgård Müller, Sébastien Selbekk, Tormod |
| description | Background
A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study.
Methods
Fifteen patients with glioblastoma (WHO grade IV) were included. All adverse events were registered in a 6-month study period. During acquisition of 3D ultrasound image volumes, three different concentrations of the ACF and Ringer’s solution were filled into the resection cavity. The effect of ACF on the ultrasound images was rated by the operating surgeon, and by five independent neurosurgeons evaluating a pair of blinded images from all patients. Images from all patients were analysed by comparing pixel brightness in a noise-affected region and a reference region.
Results
The operating surgeon deemed the ACF images to have less noise than images obtained with Ringers’s solution. The blinded evaluations by the independent neurosurgeons were significantly in favour of ACF (
p
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| doi_str_mv | 10.1007/s00701-019-03945-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6581938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232077452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389x-fb19bf5ffb5cf9470e2ba0bc786b61e267d452981ca70b86c2cfde8c17e130093</originalsourceid><addsrcrecordid>eNp9kUtuFDEQhlsIRELgAiyQJTZsGsp2d9veIEURj0iR2MDast32jKOe7sEPMqNsOAQn5CRUmBAeCzZVturz76r6m-YphZcUQLzKGIC2QFULXHV9u7vXHIPqWIsB7uMZsDywQR41j3K-xBsTHX_YHHFKoaOMHTfXp2T2V8S4peYSHcG8neK8ImGqcSRXsayJsXGKZU_KQpIfq_OkTiWZvNR5JHFjVje8ScUH40omcSY2GYylbpaaSK5p5dP--9dvhmzXJntyTnKp4_5x8yCYKfsnt_mk-fT2zcez9-3Fh3fnZ6cXreNS7dpgqbKhD8H2LqhOgGfWgHVCDnagng1i7HqmJHVGgJWDYy6MXjoqPOUAip80rw-622o3fnR-xu4nvU3Ye9rrxUT9d2WOa71avuihl1RxiQIvbgXS8rn6XPQmZuenycwe96YZ4wyEwC4Qff4Peok7mHE8pNigQMoekGIHyqUl5-TDXTMU9I23-uCtRm_1T2_1Dh89-3OMuye_zESAH4CMpRl3_vvv_8j-ALyNs-4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2226908850</pqid></control><display><type>article</type><title>A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study</title><source>Springer Link</source><creator>Unsgård, Geirmund ; Sagberg, Lisa Millgård ; Müller, Sébastien ; Selbekk, Tormod</creator><creatorcontrib>Unsgård, Geirmund ; Sagberg, Lisa Millgård ; Müller, Sébastien ; Selbekk, Tormod</creatorcontrib><description>Background
A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study.
Methods
Fifteen patients with glioblastoma (WHO grade IV) were included. All adverse events were registered in a 6-month study period. During acquisition of 3D ultrasound image volumes, three different concentrations of the ACF and Ringer’s solution were filled into the resection cavity. The effect of ACF on the ultrasound images was rated by the operating surgeon, and by five independent neurosurgeons evaluating a pair of blinded images from all patients. Images from all patients were analysed by comparing pixel brightness in a noise-affected region and a reference region.
Results
The operating surgeon deemed the ACF images to have less noise than images obtained with Ringers’s solution. The blinded evaluations by the independent neurosurgeons were significantly in favour of ACF (
p
< 0.0001). The analyses of pixel intensities showed that the ACF images had lower amount of noise than images obtained with Ringer’s solution. No radiological sign of inflammation nor circulatory changes was found in the early postoperative MR images. Of the nine complications registered as serious events in the study period, none was deemed to be caused by the ACF.
Conclusion
The ultrasound (US) images obtained using ACF have significantly less noise than US images obtained with Ringer’s solution. The rate of adverse events was comparable to what has been reported for similar groups of patients.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-019-03945-x</identifier><identifier>PMID: 31104122</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Acoustic noise ; Adult ; Artefacts ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - surgery ; Brain tumors ; Complications ; Female ; Glioblastoma ; Glioblastoma - diagnostic imaging ; Glioblastoma - surgery ; Humans ; Image acquisition ; Image quality ; Imaging, Three-Dimensional - methods ; Imaging, Three-Dimensional - standards ; Interventional Radiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minimally Invasive Surgery ; Monitoring, Intraoperative - methods ; Monitoring, Intraoperative - standards ; Neuroimaging ; Neurology ; Neuroradiology ; Neurosurgery ; Neurosurgical Procedures - adverse effects ; Neurosurgical Procedures - methods ; Noise ; Original - Brain Tumors ; Original Article - Brain Tumors ; Patients ; Postoperative Complications - epidemiology ; Signal-To-Noise Ratio ; Surgeons ; Surgery ; Surgical Orthopedics ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasonography - standards ; Ultrasound</subject><ispartof>Acta neurochirurgica, 2019-07, Vol.161 (7), p.1475-1486</ispartof><rights>The Author(s) 2019</rights><rights>Acta Neurochirurgica is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389x-fb19bf5ffb5cf9470e2ba0bc786b61e267d452981ca70b86c2cfde8c17e130093</citedby><cites>FETCH-LOGICAL-c389x-fb19bf5ffb5cf9470e2ba0bc786b61e267d452981ca70b86c2cfde8c17e130093</cites><orcidid>0000-0002-9689-3821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31104122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Unsgård, Geirmund</creatorcontrib><creatorcontrib>Sagberg, Lisa Millgård</creatorcontrib><creatorcontrib>Müller, Sébastien</creatorcontrib><creatorcontrib>Selbekk, Tormod</creatorcontrib><title>A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study.
Methods
Fifteen patients with glioblastoma (WHO grade IV) were included. All adverse events were registered in a 6-month study period. During acquisition of 3D ultrasound image volumes, three different concentrations of the ACF and Ringer’s solution were filled into the resection cavity. The effect of ACF on the ultrasound images was rated by the operating surgeon, and by five independent neurosurgeons evaluating a pair of blinded images from all patients. Images from all patients were analysed by comparing pixel brightness in a noise-affected region and a reference region.
Results
The operating surgeon deemed the ACF images to have less noise than images obtained with Ringers’s solution. The blinded evaluations by the independent neurosurgeons were significantly in favour of ACF (
p
< 0.0001). The analyses of pixel intensities showed that the ACF images had lower amount of noise than images obtained with Ringer’s solution. No radiological sign of inflammation nor circulatory changes was found in the early postoperative MR images. Of the nine complications registered as serious events in the study period, none was deemed to be caused by the ACF.
Conclusion
The ultrasound (US) images obtained using ACF have significantly less noise than US images obtained with Ringer’s solution. The rate of adverse events was comparable to what has been reported for similar groups of patients.</description><subject>Acoustic noise</subject><subject>Adult</subject><subject>Artefacts</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - surgery</subject><subject>Brain tumors</subject><subject>Complications</subject><subject>Female</subject><subject>Glioblastoma</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Glioblastoma - surgery</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Image quality</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Imaging, Three-Dimensional - standards</subject><subject>Interventional Radiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgery</subject><subject>Monitoring, Intraoperative - methods</subject><subject>Monitoring, Intraoperative - standards</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Neurosurgical Procedures - adverse effects</subject><subject>Neurosurgical Procedures - methods</subject><subject>Noise</subject><subject>Original - Brain Tumors</subject><subject>Original Article - Brain Tumors</subject><subject>Patients</subject><subject>Postoperative Complications - epidemiology</subject><subject>Signal-To-Noise Ratio</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasonography - standards</subject><subject>Ultrasound</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kUtuFDEQhlsIRELgAiyQJTZsGsp2d9veIEURj0iR2MDast32jKOe7sEPMqNsOAQn5CRUmBAeCzZVturz76r6m-YphZcUQLzKGIC2QFULXHV9u7vXHIPqWIsB7uMZsDywQR41j3K-xBsTHX_YHHFKoaOMHTfXp2T2V8S4peYSHcG8neK8ImGqcSRXsayJsXGKZU_KQpIfq_OkTiWZvNR5JHFjVje8ScUH40omcSY2GYylbpaaSK5p5dP--9dvhmzXJntyTnKp4_5x8yCYKfsnt_mk-fT2zcez9-3Fh3fnZ6cXreNS7dpgqbKhD8H2LqhOgGfWgHVCDnagng1i7HqmJHVGgJWDYy6MXjoqPOUAip80rw-622o3fnR-xu4nvU3Ye9rrxUT9d2WOa71avuihl1RxiQIvbgXS8rn6XPQmZuenycwe96YZ4wyEwC4Qff4Peok7mHE8pNigQMoekGIHyqUl5-TDXTMU9I23-uCtRm_1T2_1Dh89-3OMuye_zESAH4CMpRl3_vvv_8j-ALyNs-4</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Unsgård, Geirmund</creator><creator>Sagberg, Lisa Millgård</creator><creator>Müller, Sébastien</creator><creator>Selbekk, Tormod</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9689-3821</orcidid></search><sort><creationdate>20190701</creationdate><title>A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study</title><author>Unsgård, Geirmund ; Sagberg, Lisa Millgård ; Müller, Sébastien ; Selbekk, Tormod</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389x-fb19bf5ffb5cf9470e2ba0bc786b61e267d452981ca70b86c2cfde8c17e130093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acoustic noise</topic><topic>Adult</topic><topic>Artefacts</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - surgery</topic><topic>Brain tumors</topic><topic>Complications</topic><topic>Female</topic><topic>Glioblastoma</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Glioblastoma - surgery</topic><topic>Humans</topic><topic>Image acquisition</topic><topic>Image quality</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Imaging, Three-Dimensional - standards</topic><topic>Interventional Radiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgery</topic><topic>Monitoring, Intraoperative - methods</topic><topic>Monitoring, Intraoperative - standards</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Neurosurgical Procedures - adverse effects</topic><topic>Neurosurgical Procedures - methods</topic><topic>Noise</topic><topic>Original - Brain Tumors</topic><topic>Original Article - Brain Tumors</topic><topic>Patients</topic><topic>Postoperative Complications - epidemiology</topic><topic>Signal-To-Noise Ratio</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasonography - standards</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Unsgård, Geirmund</creatorcontrib><creatorcontrib>Sagberg, Lisa Millgård</creatorcontrib><creatorcontrib>Müller, Sébastien</creatorcontrib><creatorcontrib>Selbekk, Tormod</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Unsgård, Geirmund</au><au>Sagberg, Lisa Millgård</au><au>Müller, Sébastien</au><au>Selbekk, Tormod</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>161</volume><issue>7</issue><spage>1475</spage><epage>1486</epage><pages>1475-1486</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Background
A novel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image quality and safety in a clinical phase 1 study.
Methods
Fifteen patients with glioblastoma (WHO grade IV) were included. All adverse events were registered in a 6-month study period. During acquisition of 3D ultrasound image volumes, three different concentrations of the ACF and Ringer’s solution were filled into the resection cavity. The effect of ACF on the ultrasound images was rated by the operating surgeon, and by five independent neurosurgeons evaluating a pair of blinded images from all patients. Images from all patients were analysed by comparing pixel brightness in a noise-affected region and a reference region.
Results
The operating surgeon deemed the ACF images to have less noise than images obtained with Ringers’s solution. The blinded evaluations by the independent neurosurgeons were significantly in favour of ACF (
p
< 0.0001). The analyses of pixel intensities showed that the ACF images had lower amount of noise than images obtained with Ringer’s solution. No radiological sign of inflammation nor circulatory changes was found in the early postoperative MR images. Of the nine complications registered as serious events in the study period, none was deemed to be caused by the ACF.
Conclusion
The ultrasound (US) images obtained using ACF have significantly less noise than US images obtained with Ringer’s solution. The rate of adverse events was comparable to what has been reported for similar groups of patients.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>31104122</pmid><doi>10.1007/s00701-019-03945-x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-9689-3821</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustic noise Adult Artefacts Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - surgery Brain tumors Complications Female Glioblastoma Glioblastoma - diagnostic imaging Glioblastoma - surgery Humans Image acquisition Image quality Imaging, Three-Dimensional - methods Imaging, Three-Dimensional - standards Interventional Radiology Male Medicine Medicine & Public Health Middle Aged Minimally Invasive Surgery Monitoring, Intraoperative - methods Monitoring, Intraoperative - standards Neuroimaging Neurology Neuroradiology Neurosurgery Neurosurgical Procedures - adverse effects Neurosurgical Procedures - methods Noise Original - Brain Tumors Original Article - Brain Tumors Patients Postoperative Complications - epidemiology Signal-To-Noise Ratio Surgeons Surgery Surgical Orthopedics Ultrasonic imaging Ultrasonography - methods Ultrasonography - standards Ultrasound |
| title | A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery—a phase I study |
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