A Differential Approach to Form and Site of Peptic Ulcer

The structural organization of intestinal blood flow is such as to allow for intramural collateral flow. Redistribution phenomena due to different local metabolic demands may lead to an impaired perfusion of parts of the intestinal wall which will display a characteristic pattern. Based on Ohm’s and...

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Bibliographic Details
Published in:Scientific reports 2019-06, Vol.9 (1), p.8683-21, Article 8683
Main Authors: Rau, Walter, Hohaus, Christoph, Jessen, Eike
Format: Article
Language:English
Subjects:
639/766/747
692/420
692/699/1503/583/1722
Algorithms
Blood flow
Blood Flow Velocity
Gastrointestinal tract
Gastrointestinal Tract - blood supply
Gastrointestinal Tract - pathology
Gastrointestinal Tract - physiopathology
Humanities and Social Sciences
Humans
Intestine
Microvessels - physiopathology
Models, Biological
multidisciplinary
Peptic Ulcer - diagnosis
Peptic Ulcer - physiopathology
Perfusion
Pyloric Antrum - blood supply
Pyloric Antrum - pathology
Pyloric Antrum - physiopathology
Science
Science (multidisciplinary)
Stomach - blood supply
Stomach - pathology
Stomach - physiopathology
Stomach Ulcer - diagnosis
Stomach Ulcer - physiopathology
Ulcers
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Summary:The structural organization of intestinal blood flow is such as to allow for intramural collateral flow. Redistribution phenomena due to different local metabolic demands may lead to an impaired perfusion of parts of the intestinal wall which will display a characteristic pattern. Based on Ohm’s and Kirchhoff’s laws, a differential analysis of the gastric vascular bed bridges the gap between basic physiological concepts and traditional anatomical, pathological and clinical knowledge. An ulcer of the intestinal wall becomes understandable as a non-occlusive infarct based on a supply/demand conflict in an anisotropic structure as it can be found in the upper and lower gastrointestinal tract of man.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44893-x