Differences in Colistin Administration and Bacterial and Treatment Outcomes in Critically Ill Patients

The desired target steady-state average colistin concentration (C ss,avg ) to balance between therapeutic effectiveness and nephrotoxicity is largely unclear. The objective of this study was to evaluate the effect of the desired target colistin C ss,avg on the effectiveness and safety of IV colistin...

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Bibliographic Details
Published in:Scientific reports 2019-06, Vol.9 (1), p.8781-11, Article 8781
Main Authors: Jung, Sunmi, Chung, Eun Kyoung, Jun, Min Sun, Son, Eun Sun, Rhie, Sandy Jeong
Format: Article
Language:English
Subjects:
692/308/409
692/499
692/699/255/1318
Adult
Aged
Aged, 80 and over
Bacteremia
Bacteria - drug effects
Bacteria - isolation & purification
Clinical outcomes
Colistin
Colistin - pharmacology
Colistin - therapeutic use
Creatinine
Critical Illness
Drug therapy
Female
Humanities and Social Sciences
Humans
Male
Microbial Sensitivity Tests
Middle Aged
multidisciplinary
Patients
Risk reduction
Science
Science (multidisciplinary)
Treatment Outcome
Young Adult
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Summary:The desired target steady-state average colistin concentration (C ss,avg ) to balance between therapeutic effectiveness and nephrotoxicity is largely unclear. The objective of this study was to evaluate the effect of the desired target colistin C ss,avg on the effectiveness and safety of IV colistin therapy in critically ill patients. Overall, 153 critically ill patients (71% males) receiving IV colistin were retrospectively analyzed. The desired target colistin C ss,avg was estimated based on the daily colistin dose and creatinine clearance of each patient. No significant predictor for clinical cure was identified. However, microbiological outcome was significantly associated with pneumonia compared to bacteremia (odds ratio [OR] 0.092, 95% confidence interval [CI] [0.033–0.251], P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44965-y