One-Year Results Evaluating the Effects of Concentrated Growth Factors on the Healing of Intrabony Defects Treated with or without Bone Substitute in Chronic Periodontitis

BACKGROUND The restoration of damaged periodontium, especially one-wall intrabony defects, is a major challenge for clinicians. Concentrated growth factors (CGF) are a 100% autologous fibrin with multiple concentrated growth factors. The rigid fibrin structure of CGF makes it possible to preserve or...

Full description

Saved in:
Bibliographic Details
Published in:Medical science monitor 2019-06, Vol.25, p.4384-4389
Main Authors: Xu, Yan, Qiu, Jiling, Sun, Qinfeng, Yan, Shiguo, Wang, Wenxia, Yang, Pishan, Song, Aimei
Format: Article
Language:English
Subjects:
Adult
Alveolar Bone Loss - drug therapy
Bone Regeneration - drug effects
Bone Substitutes - pharmacology
China
Chronic Periodontitis - drug therapy
Clinical Research
Female
Fibrin - pharmacology
Follow-Up Studies
Humans
Intercellular Signaling Peptides and Proteins - pharmacology
Male
Mandibular Diseases - drug therapy
Middle Aged
Minerals - pharmacology
Periodontal Index
Periodontal Ligament
Wound Healing - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND The restoration of damaged periodontium, especially one-wall intrabony defects, is a major challenge for clinicians. Concentrated growth factors (CGF) are a 100% autologous fibrin with multiple concentrated growth factors. The rigid fibrin structure of CGF makes it possible to preserve or reconstruct the initial bone volume. The aim of this study was to evaluate the clinical healing patterns after surgical application of CGF with and without a Bio-Oss graft in one-wall infrabony defects. MATERIAL AND METHODS We randomly divided 120 one-wall intrabony defects in 54 patients into 4 groups: flap surgery alone (Group 1), flap surgery with autologous CGF (Group 2), flap surgery with Bio-Oss (Group 3), and flap surgery with CGF+Bio-Oss (Group 4). Clinical parameters such as probing depth (PD) and clinical attachment level (CAL) change were recorded at baseline and at 6 and 12 months postoperatively. RESULTS At 12 months postoperatively, Group 2 showed significant improvement in clinical parameters over Group 1 (P0.05). CONCLUSIONS CGF reduced periodontal intrabony defects depth and, when mixed with Bio-Oss, CGF showed better results in the early period and the effect was more stable.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.917025