EFFECTOR OF TRANSCRIPTION factors are novel plant-specific regulators associated with genomic DNA methylation in Arabidopsis

Plant-specific EFFECTORS OF TRANSCRIPTION (ET) are characterised by a variable number of highly conserved ET repeats, which are involved in zinc and DNA binding. In addition, ETs share a GIY-YIG domain, involved in DNA nicking activity. It was hypothesised that ETs might act as epigenetic regulators...

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Bibliographic Details
Published in:The New phytologist 2019-01, Vol.221 (1), p.261-278
Main Authors: Tedeschi, Francesca, Rizzo, Paride, Huong, Bui Thi Mai, Czihal, Andreas, Rutten, Twan, Altschmied, Lothar, Scharfenberg, Sarah, Grosse, Ivo, Becker, Claude, Weigel, Detlef, Bäumlein, Helmut, Kuhlmann, Markus
Format: Article
Language:English
Subjects:
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis - radiation effects
Arabidopsis Proteins - genetics
Arabidopsis thaliana
Cyclobutane
Cyclobutane pyrimidine dimers
Defects
Deoxyribonucleic acid
Dimers
DNA
DNA Methylation
DNA repair
EFFECTOR OF TRANSCRIPTION (ET)
Epigenesis, Genetic
Epigenetics
Flowers
Flowers - genetics
Gene expression
Gene Expression Regulation, Plant
methylome
Multigene Family
Mutation
Nicking endonuclease
Phenotype
Plants, Genetically Modified
Pyrimidine Dimers - metabolism
Pyrimidines
Regulators
Seedlings
Seedlings - genetics
Transcription
Transcription factors
Transcription Factors - genetics
Ultraviolet Rays
Whole Genome Sequencing
Zinc
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Summary:Plant-specific EFFECTORS OF TRANSCRIPTION (ET) are characterised by a variable number of highly conserved ET repeats, which are involved in zinc and DNA binding. In addition, ETs share a GIY-YIG domain, involved in DNA nicking activity. It was hypothesised that ETs might act as epigenetic regulators. Here, methylome, transcriptome and phenotypic analyses were performed to investigate the role of ET factors and their involvement in DNA methylation in Arabidopsis thaliana. Comparative DNA methylation and transcriptome analyses in flowers and seedlings of et mutants revealed ET-specific differentially expressed genes and mostly independently characteristic, ET-specific differentially methylated regions. Loss of ET function results in pleiotropic developmental defects. The accumulation of cyclobutane pyrimidine dimers after ultraviolet stress in et mutants suggests an ET function in DNA repair.
ISSN:0028-646X
1469-8137
DOI:10.1111/nph.15439