Adult stem cells at work: regenerating skeletal muscle

Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling path...

Full description

Saved in:
Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2019-07, Vol.76 (13), p.2559-2570
Main Authors: Schmidt, Manuel, Schüler, Svenja C., Hüttner, Sören S., von Eyss, Björn, von Maltzahn, Julia
Format: Article
Language:English
Subjects:
Adult
Adult Stem Cells - cytology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Differentiation
Cells (biology)
Cytoskeleton
Gene expression
Heterogeneity
Humans
Immune system
Interstitial cells
Life Sciences
Muscle Development
Muscle, Skeletal - cytology
Muscle, Skeletal - physiology
Muscles
Musculoskeletal system
Progenitor cells
Regeneration
Review
Satellite cells
Signal transduction
Signaling
Skeletal muscle
Stem cells
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions with the stem cell niche. Here, we discuss the properties of satellite cells, including heterogeneity regarding gene expression and/or their phenotypic traits and the contribution of satellite cells to skeletal muscle regeneration. We also summarize the process of regeneration with a specific emphasis on signaling pathways, cytoskeletal rearrangements, the importance of miRNAs, and the contribution of non-satellite cells such as immune cells, fibro-adipogenic progenitor cells, and PW1-positive/Pax7-negative interstitial cells.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-019-03093-6