Achieving LDL cholesterol target levels <1.81 mmol/L may provide extra cardiovascular protection in patients at high risk: Exploratory analysis of the Standard Versus Intensive Statin Therapy for Patients with Hypercholesterolaemia and Diabetic Retinopathy study

Aims To assess the benefits of intensive statin therapy on reducing cardiovascular (CV) events in patients with type 2 diabetes complicated with hyperlipidaemia and retinopathy in a primary prevention setting in Japan. In the intension‐to‐treat population, intensive therapy [targeting LDL cholestero...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2019-04, Vol.21 (4), p.791-800
Main Authors: Itoh, Hiroshi, Komuro, Issei, Takeuchi, Masahiro, Akasaka, Takashi, Daida, Hiroyuki, Egashira, Yoshiki, Fujita, Hideo, Higaki, Jitsuo, Hirata, Ken‐ichi, Ishibashi, Shun, Isshiki, Takaaki, Ito, Sadayoshi, Kashiwagi, Atsunori, Kato, Satoshi, Kitagawa, Kazuo, Kitakaze, Masafumi, Kitazono, Takanari, Kurabayashi, Masahiko, Miyauchi, Katsumi, Murakami, Tomoaki, Murohara, Toyoaki, Node, Koichi, Ogawa, Susumu, Saito, Yoshihiko, Seino, Yoshihiko, Shigeeda, Takashi, Shindo, Shunya, Sugawara, Masahiro, Sugiyama, Seigo, Terauchi, Yasuo, Tsutsui, Hiroyuki, Ueshima, Kenji, Utsunomiya, Kazunori, Yamagishi, Masakazu, Yamazaki, Tsutomu, Yo, Shoei, Yokote, Koutaro, Yoshida, Kiyoshi, Yoshimura, Michihiro, Yoshimura, Nagahisa, Nakao, Kazuwa, Nagai, Ryozo
Format: Article
Language:English
Subjects:
Aged
cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - prevention & control
Cholesterol
Cholesterol, LDL - metabolism
clinical trial
Data processing
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetic retinopathy
Diabetic Retinopathy - etiology
Diabetic Retinopathy - metabolism
dyslipidaemia
Female
Glycated Hemoglobin A - metabolism
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hyperlipidemia
Hyperlipidemias - complications
Hyperlipidemias - drug therapy
Hyperlipidemias - metabolism
Intention to Treat Analysis
Japan
lipid‐lowering therapy
Low density lipoprotein
Male
Metabolic disorders
Middle Aged
Original
Patient Care Planning
Primary Prevention
Proportional Hazards Models
Retinopathy
Statins
Statistical analysis
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Summary:Aims To assess the benefits of intensive statin therapy on reducing cardiovascular (CV) events in patients with type 2 diabetes complicated with hyperlipidaemia and retinopathy in a primary prevention setting in Japan. In the intension‐to‐treat population, intensive therapy [targeting LDL cholesterol
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.13575