The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease

Ischemic heart disease (IHD) has a genetic predisposition and a number of cardiovascular risk factors are known to be affected by genetic factors. Development of metabolic syndrome and insulin resistance, strongly influenced by lifestyle and environmental factors, frequently occur in subjects with a...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-06, Vol.98 (24), p.e15846-e15846
Main Authors: Guerini, Franca R., Ripamonti, Enrico, Costa, Andrea S., Zanzottera, Milena, Agliardi, Cristina, Bolognesi, Elisabetta, Clerici, Mario, Racca, Vittorio
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cardiac Surgical Procedures
Cohort Studies
Female
Genetic Association Studies - methods
Genetic Predisposition to Disease
Humans
INDEL Mutation
Male
Middle Aged
Myocardial Ischemia - genetics
Myocardial Ischemia - surgery
Observational Study
Polymorphism, Single Nucleotide
Prospective Studies
Synaptosomal-Associated Protein 25 - genetics
Syntaxin 1 - genetics
Vesicle-Associated Membrane Protein 2 - genetics
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Summary:Ischemic heart disease (IHD) has a genetic predisposition and a number of cardiovascular risk factors are known to be affected by genetic factors. Development of metabolic syndrome and insulin resistance, strongly influenced by lifestyle and environmental factors, frequently occur in subjects with a genetic susceptibility. The definition of genetic factors influencing disease susceptibility would allow to identify individuals at higher risk and thus needing to be closely monitored.To this end, we focused on a complex of soluble-N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), playing an important role in metabolic syndrome and insulin resistance, involved in endothelial dysfunction and heart disease. We assessed if genetic variants of the SNARE genes are associated with IHD.SNAP25 rs363050, Stx-1A rs4717806, rs2293489, and VAMP2 26bp ins/del genetic polymorphisms were analyzed in a cohort of 100 participants who underwent heart surgery; 56 of them were affected by IHD, while 44 were not. A statistical association of plasma glycemia and insulin resistance, calculated as Triglyceride glucose (TyG) index, was observed in IHD (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000015846