Metal Organic Polyhedra: A Click‐and‐Clack Approach Toward Targeted Delivery

Mixed self‐assembly of ligands 1 and 2, PXDA (3), and Pd(NO3)2 afforded metal organic polyhedra (MOP 1 – MOP 3) which bear 24 covalently attached CB[7] and cyclooctyne moieties. Post assembly modification (PAM) of MOP 3 by covalent strain promoted alkyne azide click reaction provided MOP 4R bearing...

Full description

Saved in:
Bibliographic Details
Published in:Helvetica chimica acta 2018-06, Vol.101 (6), p.n/a
Main Authors: Samanta, Soumen K., Moncelet, Damien, Vinciguerra, Brittany, Briken, Volker, Isaacs, Lyle
Format: Article
Language:English
Subjects:
Alkynes
Assembly
Biotin
cellular targeting
Covalence
cucurbit[n]uril
Drug delivery
Drug delivery systems
Flow cytometry
Fluorescein
Ligands
metal organic polyhedron
Metals
Mopping
Palladium
Polyhedra
post assembly modification
SPAAC
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mixed self‐assembly of ligands 1 and 2, PXDA (3), and Pd(NO3)2 afforded metal organic polyhedra (MOP 1 – MOP 3) which bear 24 covalently attached CB[7] and cyclooctyne moieties. Post assembly modification (PAM) of MOP 3 by covalent strain promoted alkyne azide click reaction provided MOP 4R bearing covalently attached functionality (PEG, sulfonate, biotin, c‐RGD, fluorescein, and cyanine). Orthogonal CB[7]·guest mediated non‐covalent PAM of MOP 4R with Ad‐FITC afforded MOP 5RGD•Ad‐FITC and MOP 5biotin•Ad‐FITC. Flow cytometry analysis of the uptake of MOP 5RGD•Ad‐FITC toward U87 cells demonstrated improved uptake relative to control MOP lacking c‐RGD ligands. These results suggest a broad applicability of orthogonally functionalizable (covalent and non‐covalent) MOPs in targeted drug delivery and imaging applications.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201800057