Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe

How the brain supports normal episodic memory function without medial temporal lobe (MTL) structures has not been well characterized, which could provide clues for new therapeutic targets for people with MTL dysfunction‐related memory impairment. To characterize brain network supporting effective ep...

Full description

Saved in:
Bibliographic Details
Published in:Human brain mapping 2019-05, Vol.40 (7), p.2188-2199
Main Authors: Jeong, Woorim, Lee, Hyeongrae, Kim, June Sic, Chung, Chun Kee
Format: Article
Language:English
Subjects:
Activation
Adult
Brain
Brain mapping
Brain Mapping - methods
Epilepsy, Temporal Lobe - diagnostic imaging
Epilepsy, Temporal Lobe - physiopathology
Epilepsy, Temporal Lobe - surgery
episodic memory
Female
functional connectivity
Functional magnetic resonance imaging
functional MRI
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
medial prefrontal cortex
medial temporal lobe resection
Memory, Episodic
Middle Aged
Nerve Net - diagnostic imaging
Nerve Net - physiology
Neural networks
Neuroimaging
Patients
Prefrontal cortex
Temporal cortex
Temporal lobe
Temporal Lobe - diagnostic imaging
Temporal Lobe - physiology
Temporal Lobe - surgery
Thalamus
Therapeutic applications
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:How the brain supports normal episodic memory function without medial temporal lobe (MTL) structures has not been well characterized, which could provide clues for new therapeutic targets for people with MTL dysfunction‐related memory impairment. To characterize brain network supporting effective episodic memory function in the absence of unilateral MTL, we investigated the whole‐brain cortical interactions during functional magnetic resonance imaging memory encoding paradigms of words and figures in patients who showed a normal range of memory capacity following unilateral MTL resection and healthy controls (HC). Compared to the HC, the patients showed less activation in the left inferior frontal areas and right thalamus together with greater activation in the many cortical areas including the medial prefrontal cortex (mPFC). Task‐based functional connectivity (FC) analysis revealed that the mPFC showed stronger interactions with widespread brain areas in both patient groups, including the hippocampus contralateral to the resection. Moreover, the strength of the mPFC FC predicts the individual memory capacity of the patients. Our data suggest that hyperconnectivity of distributed brain areas, especially the mPFC, is a neural mechanism for memory function in the absence of one MTL.
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.24516