Incidence of severe renal dysfunction among individuals taking warfarin and implications for non–vitamin K oral anticoagulants

• Published in: The American heart journal 2017-02, Vol.184, p.150-155
• Main Authors: Fanola, Christina L., MD, MSc, Mooney, Deirdre, MD, Cowan, Andrew J., MD, Ko, Darae, MD, Sisson, Emily K., MA, Henault, Lori E., MPH, Tripodis, Yorghos, PhD, Hylek, Elaine M., MD, MPH
• Format: Article
• Language: English
• Subjects: Age; Age Factors; Aged; Anticoagulants; Anticoagulants - metabolism; Anticoagulants - therapeutic use; Atrial Fibrillation - complications; Atrial Fibrillation - drug therapy; Cardiovascular; Cardiovascular disease; Clinical medicine; Coronary Artery Disease - epidemiology; Creatinine - blood; Data collection; Disease prevention; Drug dosages; Female; Humans; Hypertension; Incidence; Kaplan-Meier Estimate; Logistic Models; Male; Medical records; Middle Aged; Multivariate Analysis; Odds Ratio; Patients; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - epidemiology; Risk Factors; Severity of Illness Index; Stroke; Stroke - etiology; Stroke - prevention & control; Variables; Warfarin - therapeutic use
• ISSN: 0002-8703; 1097-6744; 1097-6744
• DOI: 10.1016/j.ahj.2016.08.017

Background The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal function for patients prescribed non–vitamin K oral anticoagulants. Methods Patients on warfarin for atrial fibrillation or venous thromboembolism were consecutively enrolled from January 2007 to December 2010. Baseline kidney function was assessed, and patients were followed to their first decline of kidney function to creatinine clearance