Balance and the brain: A review of structural brain correlates of postural balance and balance training in humans

• Published in: Gait & posture 2019-06, Vol.71, p.245-252
• Main Authors: Surgent, Olivia J., Dadalko, Olga I., Pickett, Kristen A., Travers, Brittany G.
• Format: Article
• Language: English
• Subjects: Balance; Brain - anatomy & histology; Brain - diagnostic imaging; Brain Mapping; Diffusion tensor imaging; Humans; Magnetic Resonance Imaging; MRI; Postural Balance; Postural control
• ISSN: 0966-6362; 1879-2219
• DOI: 10.1016/j.gaitpost.2019.05.011

•Thirty-seven studies examined brain structures involved in balance using MRI.•Balance and balance training related to 234 brain structures.•Cerebellum, basal ganglia, thalamus, and hippocampus were highly implicated.•Subcortical areas associated with balance but underrepresented in balance training.•Cerebellum implicated more in clinical populations than non-clinical populations. Background: Balance challenges are associated with not only the aging process but also a wide variety of psychiatric and neurological disorders. However, relatively little is known regarding the neural basis of balance and the effects of balance interventions on the brain. Research question: This review synthesizes the existing literature to answer the question: What are the key brain structures associated with balance? Methods: This review examined 37 studies that assessed brain structures in relation to balance assessment or intervention. These studies provided 234 findings implicating 71 brain structures. The frequency of implication for each structure was examined based upon specific methodological parameters, including study design (assessment/intervention), type of balance measured (static/dynamic), population (clinical/non-clinical), and imaging analysis technique (region of interest [ROI]/voxel-based morphometry [VBM]). Results: Although a number of structures were associated with balance across the brain, the most frequently implicated structures included the cerebellum, basal ganglia, thalamus, hippocampus, inferior parietal cortex, and frontal lobe regions. Findings in the cerebellum and brainstem were most common in studies with clinical populations, studies that used an ROI approach, and studies that measured dynamic balance. Findings in the frontal, occipital, and parietal regions were also more common in studies that measured dynamic compared to static balance. Significance: While balance appears to be a whole-brain phenomenon, a subset of structures appear to play a key role in balance and are likely implicated in balance disorders. Some of these structures (i.e., the cerebellum, basal ganglia and thalamus) have a well-appreciated role in balance, whereas other regions (i.e., hippocampus and inferior parietal cortex) are not commonly thought to be associated with balance and therefore may provide alternative explanations for the neural basis of balance. Key avenues for future research include understanding the roles of all regions involved in balance across the li