General Transformations of Object Representations in Human Visual Cortex

• Published in: The Journal of neuroscience 2018-10, Vol.38 (40), p.8526-8537
• Main Authors: Ward, Emily J, Isik, Leyla, Chun, Marvin M
• Format: Article
• Language: English
• Subjects: Brain; Brain Mapping; Enlargement; Female; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Pattern Recognition, Visual - physiology; Photic Stimulation - methods; Representations; Visual cortex; Visual Cortex - physiology
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.2800-17.2018

The brain actively represents incoming information, but these representations are only useful to the extent that they flexibly reflect changes in the environment. How does the brain transform representations across changes, such as in size or viewing angle? We conducted a fMRI experiment and a magnetoencephalography experiment in humans (both sexes) in which participants viewed objects before and after affine viewpoint changes (rotation, translation, enlargement). We used a novel approach, representational transformation analysis, to derive transformation functions that linked the distributed patterns of brain activity evoked by an object before and after an affine change. Crucially, transformations derived from one object could predict a postchange representation for novel objects. These results provide evidence of general operations in the brain that are distinct from neural representations evoked by particular objects and scenes. The dominant focus in cognitive neuroscience has been on how the brain represents information, but these representations are only useful to the extent that they flexibly reflect changes in the environment. How does the brain transform representations, such as linking two states of an object, for example, before and after an object undergoes a physical change? We used a novel method to derive transformations between the brain activity evoked by an object before and after an affine viewpoint change. We show that transformations derived from one object undergoing a change generalized to a novel object undergoing the same change. This result shows that there are general perceptual operations that transform object representations from one state to another.