Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude

• Published in: The American journal of clinical nutrition 2018-07, Vol.108 (1), p.77-91
• Main Authors: O'Callaghan, Karen M, Hennessy, Áine, Hull, George L J, Healy, Karina, Ritz, Christian, Kenny, Louise C, Cashman, Kevin D, Kiely, Mairead E
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adult; Adults; Calcium - blood; Chromatography; Diet; dietary requirements; Dietary supplements; dose-response; Dose-Response Relationship, Drug; Double-Blind Method; Double-blind studies; Female; Fetal Blood - chemistry; Gestation; Humans; Infant, Newborn; Ireland; Latitude; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolites; neonatal; ODIN; Original Research Communications; Parathyroid Hormone; Placebo effect; Pregnancy; Randomization; randomized controlled trial; Regression models; Rickets; Skin; Umbilical cord; Vitamin D; Vitamin D - administration & dosage; Vitamin D - blood; vitamin D requirements; Vitamin D3
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/nqy064

In the absence of dose-response data, Dietary Reference Values for vitamin D in nonpregnant adults are extended to pregnancy. The aim was to estimate vitamin D intake needed to maintain maternal 25-hydroxyvitamin D [25(OH)D] in late gestation at a concentration sufficient to prevent newborn 25(OH)D 25 nmol/L in 99% and ≥30 nmol/L in 95% of umbilical cord sera. This trial was registered at www.clinicaltrials.gov as NCT02506439.