Coxiella burnetii: A Pathogenic Intracellular Acidophile

Coxiella burnetii is an obligate intracellular pathogen that causes acute and chronic Q fever. C. burnetii grows within a eukaryotic host cell in a vacuole highly similar to a phagolysosome. Found worldwide, this environmentally stable pathogen is maintained in nature via chronic infection of rumina...

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Bibliographic Details
Published in:Microbiology (Society for General Microbiology) 2019-01, Vol.165 (1), p.1-3
Main Authors: Shaw, Edward I, Voth, Daniel E
Format: Article
Language:English
Subjects:
Acids - metabolism
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacterial Secretion Systems - genetics
Bacterial Secretion Systems - metabolism
Coxiella burnetii - classification
Coxiella burnetii - genetics
Coxiella burnetii - isolation & purification
Coxiella burnetii - metabolism
Genome, Bacterial
Humans
Hydrogen-Ion Concentration
Microbe Profile
Phylogeny
Q Fever - microbiology
Vacuoles - chemistry
Vacuoles - microbiology
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Description
Summary:Coxiella burnetii is an obligate intracellular pathogen that causes acute and chronic Q fever. C. burnetii grows within a eukaryotic host cell in a vacuole highly similar to a phagolysosome. Found worldwide, this environmentally stable pathogen is maintained in nature via chronic infection of ruminants. Aerosol-mediated infection of humans results in infection and usurpation of alveolar macrophages through mechanisms using a bacterial Type 4B Secretion System and secreted effector proteins. Advances in axenic culture and genetic systems are changing our understanding of the pathogen's physiology and intimate molecular manipulations of host cells during infection.
ISSN:1350-0872
1465-2080
DOI:10.1099/mic.0.000707