Pathogenicity and Virulence of Trueperella pyogenes : A Review

Bacteria from the species are a part of the biota of skin and mucous membranes of the upper respiratory, gastrointestinal, or urogenital tracts of animals, but also, opportunistic pathogens. causes a variety of purulent infections, such as metritis, mastitis, pneumonia, and abscesses, which, in live...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-06, Vol.20 (11), p.2737
Main Authors: Rzewuska, Magdalena, Kwiecień, Ewelina, Chrobak-Chmiel, Dorota, Kizerwetter-Świda, Magdalena, Stefańska, Ilona, Gieryńska, Małgorzata
Format: Article
Language:English
Subjects:
Abscesses
Animals
Bacteria
Biofilms
Breeding
Cholesterol
Colonization
Cytolysins
Cytolytic activity
Deoxyribonucleic acid
DNA
Economic impact
Extracellular matrix
Fourier transforms
Gene expression
Genomes
Infections
Life sciences
Livestock
Mastitis
Metritis
Opportunist infection
Pathogenicity
Pathogens
Pili
Plasmids
Pore formation
Pyolysin
Review
Signal transduction
Skin
Trueperella pyogenes
Virulence
Virulence factors
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Summary:Bacteria from the species are a part of the biota of skin and mucous membranes of the upper respiratory, gastrointestinal, or urogenital tracts of animals, but also, opportunistic pathogens. causes a variety of purulent infections, such as metritis, mastitis, pneumonia, and abscesses, which, in livestock breeding, generate significant economic losses. Although this species has been known for a long time, many questions concerning the mechanisms of infection pathogenesis, as well as reservoirs and routes of transmission of bacteria, remain poorly understood. Pyolysin is a major known virulence factor of that belongs to the family of cholesterol-dependent cytolysins. Its cytolytic activity is associated with transmembrane pore formation. Other putative virulence factors, including neuraminidases, extracellular matrix-binding proteins, fimbriae, and biofilm formation ability, contribute to the adhesion and colonization of the host tissues. However, data about the pathogen-host interactions that may be involved in the development of infection are still limited. The aim of this review is to present the current knowledge about the pathogenic potential and virulence of .
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20112737