Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

• Published in: Scientific reports 2019-07, Vol.9 (1), p.9439-8, Article 9439
• Main Authors: Liu, Ching-Ti, Merino, Jordi, Rybin, Denis, DiCorpo, Daniel, Benke, Kelly S., Bragg-Gresham, Jennifer L., Canouil, Mickaël, Corre, Tanguy, Grallert, Harald, Isaacs, Aaron, Kutalik, Zoltan, Lahti, Jari, Marullo, Letizia, Marzi, Carola, Rasmussen-Torvik, Laura J., Rocheleau, Ghislain, Rueedi, Rico, Scapoli, Chiara, Verweij, Niek, Vogelzangs, Nicole, Willems, Sara M., Yengo, Loïc, Bakker, Stephan J. L., Beilby, John, Hui, Jennie, Kajantie, Eero, Müller-Nurasyid, Martina, Rathmann, Wolfgang, Balkau, Beverley, Bergmann, Sven, Eriksson, Johan G., Florez, Jose C., Froguel, Philippe, Harris, Tamara, Hung, Joseph, James, Alan L., Kavousi, Maryam, Miljkovic, Iva, Musk, Arthur W., Palmer, Lyle J., Peters, Annette, Roussel, Ronan, van der harst, Pim, van Duijn, Cornelia M., Vollenweider, Peter, Barroso, Inês, Prokopenko, Inga, Dupuis, Josée, Meigs, James B., Bouatia-Naji, Nabila
• Format: Article
• Language: English
• Subjects: 45; 45/43; 631/208/1516; 692/699/2743/137/773; Blood glucose; Blood Glucose - analysis; Blood Glucose - genetics; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Fasting; Female; Genetic diversity; Genetic effects; Genetic variance; Genetic Variation; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genotype; Glucose; Humanities and Social Sciences; Humans; Laboratory testing; Life Sciences; Longitudinal Studies; Male; Middle Aged; multidisciplinary; Phenotype; Polymorphism, Single Nucleotide; Science; Science (multidisciplinary); White People - genetics
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-45823-7

Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fasting glucose measurements obtained over up to 14 years of observation. We tested for associations of genetic variants with inverse-normal transformed fasting glucose change over time adjusting for age at baseline, sex, and principal components of genetic variation. We found no genome-wide significant association (P