A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

Chromolaena odorata L. (Asteraceae) is one of the tropical plants which is widely used as traditional medicines for diabetes and soft tissue wounds treatment in some regions in East Indonesia. The present study was aimed at determining the bioactive compounds of C. odorata leaves. The methanol and e...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2019, Vol.2019 (2019), p.1-12
Main Authors: Putri, Devi Anggraini, Fatmawati, Sri
Format: Article
Language:English
Subjects:
Acetic acid
Acids
Antioxidants
Bioactive compounds
Biological activity
Chromatography
Chromolaena odorata
Diabetes mellitus
Ethyl acetate
Flavonoids
Free radicals
Glucosidase
Herbal medicine
Intestine
Leaves
Medicinal plants
Methanol
Solvents
Sulfonic acid
Tropical plants
Vitamin E
α-Glucosidase
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Summary:Chromolaena odorata L. (Asteraceae) is one of the tropical plants which is widely used as traditional medicines for diabetes and soft tissue wounds treatment in some regions in East Indonesia. The present study was aimed at determining the bioactive compounds of C. odorata leaves. The methanol and ethyl acetate extracts of C. odorata leaves have the inhibitory activity against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals as well as α-glucosidase rat intestine enzyme. A new flavanone was isolated from the methanol extract and elucidated as 5,3’-dihydroxy-7,6’-dimethoxyflavanone or, namely, odoratenin (1) together with two known compounds: isosakuranetin (2) and subscandenin (3). The antioxidant activity of odoratenin (1) exhibited very potent ABTS radical inhibitory activity with IC50 value of 23.74 μM which is lower than that of trolox (IC50 31.32 μM) as a positive control. The result showed that a new flavanone, odoratenin (1), should be potential as an antioxidant source.
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/1453612