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Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory
Fear memories typically persist for long time periods, and persistent fear memories contribute to post-traumatic stress disorder. However, little is known about the cellular and synaptic mechanisms that perpetuate long-term memories. Here, we find that mouse hippocampal CA1 neurons exhibit biphasic...
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Published in: | The Journal of neuroscience 2015-01, Vol.35 (2), p.819-830 |
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creator | Nakayama, Daisuke Iwata, Hirokazu Teshirogi, Chie Ikegaya, Yuji Matsuki, Norio Nomura, Hiroshi |
description | Fear memories typically persist for long time periods, and persistent fear memories contribute to post-traumatic stress disorder. However, little is known about the cellular and synaptic mechanisms that perpetuate long-term memories. Here, we find that mouse hippocampal CA1 neurons exhibit biphasic Arc (also known as Arg3.1) elevations after fear experience and that the late Arc expression regulates the perpetuation of fear memoires. An early Arc increase returned to the baseline after 6 h, followed by a second Arc increase after 12 h in the same neuronal subpopulation; these elevations occurred via distinct mechanisms. Antisense-induced blockade of late Arc expression disrupted memory persistence but not formation. Moreover, prolonged fear memories were associated with the delayed, specific elimination of dendritic spines and the reactivation of neuronal ensembles formed during fear experience, both of which required late Arc expression. We propose that late Arc expression refines functional circuits in a delayed fashion to prolong fear memory. |
doi_str_mv | 10.1523/jneurosci.2525-14.2015 |
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subjects | Animals CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - physiology Conditioning, Classical Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Dendritic Spines - metabolism Dendritic Spines - physiology Fear Male Memory Mice Mice, Inbred C57BL Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Reaction Time |
title | Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory |
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