Cell assemblies of the basal forebrain

The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive aff...

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Bibliographic Details
Published in:The Journal of neuroscience 2015-02, Vol.35 (7), p.2992-3000
Main Authors: Tingley, David, Alexander, Andrew S, Quinn, Laleh K, Chiba, Andrea A, Nitz, Douglas A
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Attention - physiology
Basal Forebrain - cytology
Beta Rhythm - physiology
Male
Nerve Net - physiology
Neurons - classification
Neurons - physiology
Photic Stimulation
Rats
Space Perception - physiology
Time Factors
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Summary:The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive afferents. This architecture enables the basal forebrain to selectively modulate cortical responsiveness according to current processing demands. Theoretically, optimal functioning of this distributed network would be enhanced by temporal coordination among coactive basal forebrain neurons, or the emergence of "cell assemblies." The present work demonstrates assembly formation in rat basal forebrain neuronal populations during a selective attention task. Neuron pairs exhibited coactivation patterns organized within beta-frequency time windows (55 ms), regardless of their membership within distinct bursting versus nonbursting basal forebrain subpopulations. Thus, the results reveal a specific temporal framework for integration of information within basal forebrain networks and for the modulation of cortical responsiveness.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.4432-14.2015