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Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission

The cerebral innate immune system is able to modulate brain functioning and cognitive processes. During activation of the cerebral innate immune system, inflammatory factors produced by microglia, such as cytokines and adenosine triphosphate (ATP), have been directly linked to modulation of glutamat...

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Published in:The Journal of neuroscience 2015-02, Vol.35 (7), p.3022-3033
Main Authors: Delpech, Jean-Christophe, Saucisse, Nicolas, Parkes, Shauna L, Lacabanne, Chloe, Aubert, Agnes, Casenave, Fabrice, Coutureau, Etienne, Sans, Nathalie, Layé, Sophie, Ferreira, Guillaume, Nadjar, Agnes
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container_issue 7
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container_title The Journal of neuroscience
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creator Delpech, Jean-Christophe
Saucisse, Nicolas
Parkes, Shauna L
Lacabanne, Chloe
Aubert, Agnes
Casenave, Fabrice
Coutureau, Etienne
Sans, Nathalie
Layé, Sophie
Ferreira, Guillaume
Nadjar, Agnes
description The cerebral innate immune system is able to modulate brain functioning and cognitive processes. During activation of the cerebral innate immune system, inflammatory factors produced by microglia, such as cytokines and adenosine triphosphate (ATP), have been directly linked to modulation of glutamatergic system on one hand and learning and memory functions on the other hand. However, the cellular mechanisms by which microglial activation modulates cognitive processes are still unclear. Here, we used taste memory tasks, highly dependent on glutamatergic transmission in the insular cortex, to investigate the behavioral and cellular impacts of an inflammation restricted to this cortical area in rats. We first show that intrainsular infusion of the endotoxin lipopolysaccharide induces a local inflammation and increases glutamatergic AMPA, but not NMDA, receptor expression at the synaptic level. This cortical inflammation also enhances associative, but not incidental, taste memory through increase of glutamatergic AMPA receptor trafficking. Moreover, we demonstrate that ATP, but not proinflammatory cytokines, is responsible for inflammation-induced enhancement of both associative taste memory and AMPA receptor expression in insular cortex. In conclusion, we propose that inflammation restricted to the insular cortex enhances associative taste memory through a purinergic-dependent increase of glutamatergic AMPA receptor expression at the synapse.
doi_str_mv 10.1523/JNEUROSCI.3028-14.2015
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source Open Access: PubMed Central
subjects Animals
Association Learning - drug effects
Association Learning - physiology
Cognitive science
Corticosterone - blood
Cytokines - metabolism
Disease Models, Animal
Encephalitis - blood
Encephalitis - chemically induced
Encephalitis - physiopathology
Glutamic Acid - metabolism
Lipopolysaccharides - pharmacology
Lithium Chloride - pharmacology
Male
Memory - drug effects
Memory - physiology
Microglia - drug effects
Microglia - metabolism
Neuroscience
Protein Transport - drug effects
Psychology
Purinergic Agents
Rats
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Taste - drug effects
Taste - physiology
title Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission
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