Cystic and solitary nodular pulmonary metastases in a patient with low-grade endometrial stromal sarcoma: A case report and literature review

• Published in: Oncology letters 2019-08, Vol.18 (2), p.1133-1144
• Main Authors: Xu, Yang, Liang, Zhi-Xin, Guo, Jun-Tang, Su, Xin, Lu, Yun-Long, Guan, Xi-Zhou
• Format: Article
• Language: English
• Subjects: Alcohol; Cancer metastasis; Case reports; Cysts; Drinking water; Endometrial cancer; Estrogens; Health aspects; Hysterectomy; Literature reviews; Lung cancer; Medical imaging; Metastasis; Oncology; Pain; Phenols (Class of compounds); Pneumothorax; Progesterone; Sarcoma; Sex hormones; Surgery; Tumors
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2019.10409

Pulmonary metastases of endometrial stromal sarcoma (ESS) are uncommon and can be difficult to diagnose. The aims of the present study were to investigate the clinical and pathological features, and enhance the awareness of pulmonary metastases in patients with low-grade ESS. The study reports a case of low-grade ESS that resulted in cystic and nodular pulmonary metastases. Furthermore, the PubMed database was searched using 'pulmonary metastases of low-grade endometrial stromal sarcoma' as the key phrase. The literature on pulmonary metastases of low-grade ESS was reviewed and 35 cases were included in the present study. The clinical manifestations, imaging data, pathological features, treatment and prognosis of the 35 previously reported cases and the current case were retrospectively analyzed. The age range of the 36 patients diagnosed with low-grade ESS was 28-65 years. The time period from confirmation of ESS to lung metastases was 1.5-27 years. In 50% of the patients, the pulmonary metastases were asymptomatic. The most common pulmonary symptom was dyspnea, followed by chest pain, pneumothorax and coughing. The most common chest imaging presentation was multiple pulmonary nodules, followed by a solitary nodule or mass. Histology was used to identify that the pulmonary metastases had the pathological features of low-grade ESS. The immunohistochemical results demonstrated strong diffuse immunoreactivity for cluster of differentiation 10, estrogen receptor and progesterone receptor in almost all the specimens. The review of the literature revealed that pulmonary metastases from low-grade ESS are rare but not negligible. Furthermore, the detailed clinical information, imaging findings and immunohistochemical detection are important for making a diagnosis.