Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines

Cervical cancer (CC) is classified as the fourth most common type of cancer in women worldwide and remains a serious public health problem in many underdeveloped countries. Human papillomavirus (HPV), mainly types 16 and 18, has been established as a precursory etiologic agent for this type of cance...

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Published in:Evidence-based complementary and alternative medicine 2019-01, Vol.2019 (2019), p.1-8
Main Authors: Crispim, Janaina Cristiana de Oliveira, Fernandes-Pedrosa, Matheus de Freitas, Rocha, Hugo Alexandre Oliveira, Silva, Wilmar Dias da, Araújo, Josélio Maria Galvão de, Gomes, Dayanne Lopes, Farias, Kleber Juvenal Silva, Bernardes-Oliveira, Emanuelly, Donadi, Eduardo Antônio
Format: Article
Language:English
Subjects:
Apoptosis
Arthropods
Biological activity
Breast cancer
Cancer therapies
Caspase inhibitors
Cell cycle
Cell death
Cervical cancer
Cervix
Chemotherapy
Cytotoxicity
Flow cytometry
Human papillomavirus
Peptides
Public health
Radiation therapy
Tityus serrulatus
Tumor cell lines
Tumor cells
Venom
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Summary:Cervical cancer (CC) is classified as the fourth most common type of cancer in women worldwide and remains a serious public health problem in many underdeveloped countries. Human papillomavirus (HPV), mainly types 16 and 18, has been established as a precursory etiologic agent for this type of cancer. Several therapeutic attempts have been studied and applied, aiming at its control. However, not only do classical treatments such as chemotherapies and radiotherapies target tumor cells, but also they cause damage to several healthy cells. For these reasons, the search for new biologically active chemotherapeutic components is of great importance. In this study, we investigated the effect of Tityus serrulatus scorpion venom (TsV) on CC lines. There are very few studies exploring venom of scorpions, and, to our knowledge, no study has been conducted using the venom of the scorpion TsV for treatment of cervical cancer lines. After challenge with TsV, the MTT assay demonstrated cytotoxic effect on HeLa line. Similarly, the cell death process in HeLa analyzed by flow cytometry suggests death via caspase, since the pan-caspase inhibitor z-VAD-fmk significantly reduced the apoptotic response to the treatment. These results suggest that venom of TsV can be a potential source for the isolation of effective antiproliferative and apoptotic molecules in the treatment of CC.
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/5131042