Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

• Published in: BioMed research international 2019-01, Vol.2019 (2019), p.1-7
• Main Authors: Yang, Yuan, Zhou, Yanping
• Format: Article
• Language: English
• Subjects: Alveoli; Animals; Asthma; Biomedical research; Bronchus; Chinese medicine; Cytokines; Dexamethasone; Dexamethasone - pharmacology; Disease; Drug dosages; Drugs, Chinese Herbal - pharmacology; Immune response; Inflammation; Interferon; Interferon-gamma - immunology; Interleukin 4; Interleukin-4 - immunology; Laboratory animals; Lymphocytes; Lymphocytes T; Male; Neurosciences; Pharmacology; Pharmacy; Radiation; Radiation Injuries, Experimental - drug therapy; Radiation Injuries, Experimental - immunology; Radiation Injuries, Experimental - pathology; Radiation Pneumonitis - drug therapy; Radiation Pneumonitis - immunology; Radiation Pneumonitis - pathology; Rats; Rats, Sprague-Dawley; Th1 Cells - immunology; Th1 Cells - pathology; Th2 Cells - immunology; Th2 Cells - pathology; γ-Interferon
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2019/6012473

Objective. Studying correlative changes of Th1/Th2 (Th, Helper T cells) related factor Interferon-γ (IFN-γ) and Interleukin-4 (IL-4) in the progression of radiation pneumonia (RP) rats and the efficacy of Shashen-Maidong decoction on these indexes to explore the immune mechanism of the decoction on the prevention and treatment of RP. Methods. Male 60 Sprague-Dawley (SD) rats were randomly divided into four groups. In addition to the normal control group taking saline, the other rats were set up RP model treated with Shashen-Maidong decoction or dexamethasone (DXM), respectively. The IFN-γ and IL-4 concentrations in serum and bronchoalveolar lavage fluid (BALF) of rats were tested in the 2nd and 4th week after radiation, and the relative ratio of IFN-γ/IL-4 was calculated. Results. (1) There was significant difference of serum IL-4 concentrations in group B (p