Prognostic significance of periostin in colorectal cancer

Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is obs...

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Bibliographic Details
Published in:Chinese journal of cancer research 2019-06, Vol.31 (3), p.547-556
Main Authors: Deng, Xingming, Ao, Sheng, Hou, Jianing, Li, Zhuofei, Lei, Yunpeng, Lyu, Guoqing
Format: Article
Language:English
Subjects:
Review
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Summary:Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.
ISSN:1000-9604
1993-0631
DOI:10.21147/j.issn.1000-9604.2019.03.16