Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens

In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class...

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Bibliographic Details
Published in:Cancer cell 2018-08, Vol.34 (2), p.181-183
Main Authors: Hoyos, Luisa Escobar, Abdel-Wahab, Omar
Format: Article
Language:English
Subjects:
Alternative Splicing
Antigens
Humans
Mutation
Neoplasms
RNA Splicing
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Summary:In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens. In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2018.07.008