Biomarkers to assess the utility of potential reduced exposure tobacco products

To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular d...

Full description

Saved in:
Bibliographic Details
Published in:Nicotine & tobacco research 2006-08, Vol.8 (4), p.600-622
Main Authors: Hatsukami, Dorothy K, Benowitz, Neal L, Rennard, Stephen I, Oncken, Cheryl, Hecht, Stephen S
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Carcinogens - analysis
Cardiovascular Diseases - physiopathology
Fetus - drug effects
Humans
Lung Diseases - physiopathology
Neoplasms - physiopathology
Respiratory Function Tests
Sensitivity and Specificity
Smoking - adverse effects
Tobacco Products
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.
ISSN:1462-2203
1469-994X
DOI:10.1080/14622200600858166