Nomograms predicting overall survival and cancer-specific survival in osteosarcoma patients (STROBE)

The aim of this study was to develop nomograms to predict long-term overall survival and cancer-specific survival of patients with osteosarcoma.We carried out univariate and multivariate analyses and set up nomograms predicting survival outcome using osteosarcoma patient data collected from the Surv...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-06, Vol.98 (26), p.e16141-e16141
Main Authors: Chen, Wenhao, Lin, Yuxiang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Nomograms
Observational Study
Osteosarcoma - diagnosis
Osteosarcoma - mortality
Osteosarcoma - pathology
Osteosarcoma - therapy
SEER Program
Survival Analysis
Young Adult
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Summary:The aim of this study was to develop nomograms to predict long-term overall survival and cancer-specific survival of patients with osteosarcoma.We carried out univariate and multivariate analyses and set up nomograms predicting survival outcome using osteosarcoma patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute (2004-2011, n = 1426). The patients were divided into a training cohort (2004-2008, n = 863) and a validation cohort (2009-2011, n = 563), and the mean follow-up was 55 months.In the training cohort, 304 patients (35.2%) died from osteosarcoma and 91 (10.5%) died from other causes. In the validation cohort, 155 patients (27.5%) died from osteosarcoma and (12.3%) died from other causes. Nomograms predicting overall survival (OS) and cancer-specific survival (CSS) were developed according to 6 clinicopathologic factors (age, tumor site, historic grade, surgery, AJCC T/N, and M), with concordance indexes (C-index) of 0.725 (OS) and 0.718 (CSS), respectively. The validation C-indexes were 0.775 and 0.742 for OS and CSS, respectively.Our results suggest that we have successfully developed highly accurate nomograms for predicting 5-year OS and CSS for osteosarcoma patients. These nomograms will help surgeons customize treatment and monitoring strategies for osteosarcoma patients.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000016141