Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their gene...

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Bibliographic Details
Published in:Cancers 2019-06, Vol.11 (6), p.845
Main Authors: van der Kooij, Monique K, Speetjens, Frank M, van der Burg, Sjoerd H, Kapiteijn, Ellen
Format: Article
Language:English
Subjects:
Antigens
Cancer therapies
Cell cycle
Cell growth
Chromosomes
DNA methylation
Embryos
Immunotherapy
Investigations
Kinases
Medical prognosis
Melanocytes
Melanoma
Metastases
Metastasis
Mutation
Proteins
Response rates
Review
Skin
Tumors
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Summary:Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11060845