Microtubule control of functional architecture in neurons

•Regulation of non-centrosomal microtubule organization in neurons.•Role of resilient acetylated microtubules in mechanosensation.•Patterning microtubule tracks to deliver cargo to the right place at the right time. Neurons are exquisitely polarized cells whose structure and function relies on micro...

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Bibliographic Details
Published in:Current opinion in neurobiology 2019-08, Vol.57, p.39-45
Main Authors: Kelliher, Michael T, Saunders, Harriet AJ, Wildonger, Jill
Format: Article
Language:English
Subjects:
Microtubule-Associated Proteins
Microtubules
Neurons
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Summary:•Regulation of non-centrosomal microtubule organization in neurons.•Role of resilient acetylated microtubules in mechanosensation.•Patterning microtubule tracks to deliver cargo to the right place at the right time. Neurons are exquisitely polarized cells whose structure and function relies on microtubules. Microtubules in signal-receiving dendrites and signal-sending axons differ in their organization and microtubule-associated proteins. These differences, coupled with microtubule post-translational modifications, combine to locally regulate intracellular transport, morphology, and function. Recent discoveries provide new insight into the regulation of non-centrosomal microtubule arrays in neurons, the relationship between microtubule acetylation and mechanosensation, and the spatial patterning of microtubules that regulates motor activity and cargo delivery in axons and dendrites. Together, these new studies bring us closer to understanding how microtubule function is locally tuned to match the specialized tasks associated with signal reception and transmission.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2019.01.003